Looking at Denver's offense last season under Rick Dennison they liked to spread the ball to (2) wide receivers with 281 combined targets.
In fact they had (2) receivers over 1000 yards- Emmanual Sanders and Demaryius Thomas. They did not use their TEs very much, only 57 combined targets to Green and Derby.
The Bills really have only one NFL starting quality WR currently on the roster- Sammy Watkins- and he has not shown very durable.
Corey Brown, the recent pickup from the Panthers is currently slotted as the no.2 WR but he is not very good. caught only 50% of passes thrown his way last season and will likely be on special teams duties.
Seems like a very strong possibility the Bills will go WR and #10 and beyond.