The "real" offense, ie, first team, has been out there early in games, and it has sucked. All this chatter about "playing vanilla" and working "on stuff they need to work on" is a lot of whistling past the graveyard. Other teams' first team offenses manage to produce drives and score TDs in the first two preseason games, but the Bills can barely get two first downs in a row. Every third or fourth play, they get caught holding. The only Bills offensive starters who seem to have played well have been Shady and Sammy, who is now in LA.
When the starters on any unit consistently play poor in preseason, it's a sure signal that that unit is going to struggle in the regular season. It's likely the Bills are going to have to depend on the defense to not only stop opponents' offenses but to do much of the scoring as well.
No, it's not really a sure thing that they will struggle in the regular season. Actually, preseason success is a terrible indicator of regular season results.
There have been plenty of teams that went 0-4 in the preseason and went on to have good seasons. For just 1 example- The 1990 Bills. They sucked in preseason that year, could hardly score, went 0-4. Then won 13 games in the regular season and went to their 1st Super Bowl.
And there's been plenty of teams that went 4-0 in preseason and went on to suck in regular season. Like the 2008 Lions for ex. They went undefeated during preseason, looked great and people were hyping them up. Then they went 0-16 in the regular season that year.
Or the Rams in 2011. Went 4-0 preseason, 2-14 regular season. Actually, the last I looked, teams that went 4-0 in the preseason missed the playoffs more times than not.
Im not saying the Bills are going to be great this year, but I'm definitely not ready to panic yet and you surely can't say that it's a "sure sign" the offense will suck from 2 preseason games with no game plan, totally vanilla schemes and an O Line that struggled mightily.